| Autor: |
Meidai Fan, Rongrong Li, Cui Xiaohui, Zhenzhen Yang, Xin Chen, Bailing Zhang, Xinyi Shi, Limin Zhang, Guoke Yang, Gang Zhang, Qingchang Fang, Wang Xin, Ying Meng, Xiaojuan Diao, Taihua Wang, Lina Zhao |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Advances in Tissue Engineering & Regenerative Medicine: Open Access. 4 |
| ISSN: |
2572-8490 |
| DOI: |
10.15406/atroa.2018.04.00078 |
| Popis: |
Since the discovery that insulin can reduce blood glucose levels in exogenous insulin administration becomes the standard method to treat human diabetes patients Yet this method cannot efficiently prevent the development of diabetes complications Here we report a combinatorial strategy that combines human pluripotent stem cells and overexpression of estrogen related receptor gamma ERR gamma together which in theory not only can repair the damaged tissues and restore the function of human pancreatic beta cells but also can synthesize and secrete human insulin so that to reduce the blood glucose levels of the diabetic patients after transplantation Our preliminary investigation demonstrated that our method can efficiently secrete human insulin increase the secretion of human C peptide and improve the patient rsquo s health conditions physically and mentally thus with the potential to prevent and even to reverse human diabetic complications with more transplantations Our reports laid an important foundation for treating human diabetes and eventually cure this disease |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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