Protective Effect ofPelargonium graveolensEssential Oil Against Alloxan-Induced Diabetes and Oxidative Stress in Rats
| Autor: | Mohamed Lamjed Marzouki, Hichem Sebai, Kaies Rtibi, Azhar Hajri, Slimen Selmi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Antioxidant
medicine.medical_treatment Intraperitoneal injection Context (language use) Plant Science Pharmacology Toxicology medicine.disease_cause 01 natural sciences law.invention chemistry.chemical_compound law Diabetes mellitus Alloxan Drug Discovery medicine Essential oil biology 010405 organic chemistry business.industry biology.organism_classification medicine.disease Agricultural and Biological Sciences (miscellaneous) 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Biochemistry chemistry Pelargonium graveolens business Oxidative stress |
| Zdroj: | Journal of Biologically Active Products from Nature. 6:299-314 |
| ISSN: | 2231-1874 2231-1866 |
| Popis: | Oxidative stress occurs in diabetic patients and experimental models of diabetes. The antioxidant property of Pelargonium graveolens essential oil (PGEO) might have a beneficial effect in ameliorating the disease. In this context, the aim of the present study was to investigate the effects of PGEO on oxidative stress in alloxan-induced diabetes in rats. The antidiabetic and antioxidant activities were evaluated after sub-acute intraperitoneal injection of male rats to 42.5 mg/kg b.w. essential oil for 21 days. In results, we found that PGEO significantly protected against the increase of blood glucose induced by alloxan treatment. In addition, we showed that sub-acute essential oil treatment induced a decrease of lipoperoxydation, as well as, the induction of antioxidant enzyme activities. The use of GC-MS technique revealed the identification of many compounds in PGEO with (R)-citronellol (31.61%) as the main compound. The protective effect of PGEO is mainly attributed to antioxidant property. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|