Demyelinating disease in a woman from tropical South America with features of multiple sclerosis and neuromyelitis optica
| Autor: | E.H. Jellinek, D.A. Howell, K. Gavrilescu |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Pathology
medicine.medical_specialty Neuromyelitis optica medicine.diagnostic_test business.industry Multiple sclerosis Grey matter medicine.disease Artificial respiration medicine.anatomical_structure Neurology medicine Demyelinating disease Neurology (clinical) Differential diagnosis business Myelography Pathological |
| Zdroj: | Journal of the Neurological Sciences. 7:115-135 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/0022-510x(68)90008-7 |
| Popis: | The case history of a patient who developed a demyelinating disease in tropical South America is described. The early history was suggestive of multiple sclerosis; the later history of neuromyelitis optica. Her life was prolonged by artificial respiration, but some anoxic episodes occurred. The problems of diagnosis and the geographical distribution of demyelinating diseases are discussed. The protein studies of the serum and cerebrospinal fluid suggest that the patient suffered from a kind of demyelinating disease not previously encountered in the Northern Hemisphere, in our experience, perhaps an intense variant of multiple sclerosis. At necropsy lesions in the grey matter were found and attributed to anoxia. In addition cystic lesions and lesions similar to plaques of multiple sclerosis were found. Wide-spread perivascular cuffing with small round cells was present even in areas showing no other manifestations of disease. Astrocytic fibres were infrequent. The spinal cord, in addition, showed severe destruction. Myelin sheaths similar to those of peripheral nerves were plentiful. The nature of the pathological process and its relationship to other demyelinating diseases are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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