Immunothérapie et cancer du poumon : nouveaux concepts
| Autor: | A.-G. Goubet, Alain Livartowski, E. Romano |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Tumor microenvironment business.industry medicine.drug_class animal diseases medicine.medical_treatment Immune checkpoint inhibitors chemical and pharmacologic phenomena Immunotherapy biochemical phenomena metabolism and nutrition medicine.disease Monoclonal antibody 03 medical and health sciences 030104 developmental biology Immune system Cancer research bacteria Medicine business Lung cancer |
| Zdroj: | Revue des Maladies Respiratoires. 35:642-651 |
| ISSN: | 0761-8425 |
| DOI: | 10.1016/j.rmr.2018.03.001 |
| Popis: | Improvements in knowledge about the complexity of the tumor microenvironment have paved the way for a revolution in lung cancer treatment with the emergence of immune checkpoint inhibitors. The immune checkpoints negatively regulate immune cells and lead to a dormant state: the immune cells are then unable to interact effectively with their targets. The immune checkpoint inhibitors are monoclonal antibodies that block immune checkpoints and permit reactivation of the immune response against the tumor. Although immune checkpoint inhibitors are effective as monotherapy, several other immune targets exist. The better understanding of the involvement of these new targets in the immune response against tumors is leading to the design of new compounds and new therapeutic approaches. |
| Databáze: | OpenAIRE |
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