| Autor: |
F. Simenthal, A. Hornedo-Nuñez, T.A. Getek, Walter A. Korfmacher |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Journal of Chromatography A. 503:217-225 |
| ISSN: |
0021-9673 |
| DOI: |
10.1016/s0021-9673(01)81503-x |
| Popis: |
The high-performance liquid chromatographic analysis of clindamycin phosphate and clindamycin hydrochloride was accomplished by using a mobile phase consisting of the ion pair reagent, sodium pentane sulfonate, and a reversed-phase ODS-II column. Detection was performed with a dual electrochemical cell at a screening potential of +0.7 V and a detecting potential of +0.9 V. Limits of detection for clindamycin were 100 pg injected on-column utilizing a pulse-free syringe pump. Bulk preparations of clindamycin hydrochloride were analyzed by high-performance liquid chromatography (HPLC) with electrochemical detection and compared to an HPLC technique utilizing ultraviolet detection at 214 nm. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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