Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants

Autor:	Kenji Miyamoto, Robert Kourist, Hiromichi Ohta, Daisuke Uemura, Shosuke Yoshida, Takashi Kumon, Reina Wada
Rok vydání:	2013
Předmět:	biology Strain (chemistry) Chemistry Stereochemistry Decarboxylation Organic Chemistry Sulfolobus tokodaii Active site Biochemistry Esterase Catalysis Cascade reaction Drug Discovery biology.protein Organic chemistry Stereoselectivity
Zdroj:	Tetrahedron Letters. 54:1921-1923
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2013.01.080
Popis:	We have developed a thermally driven domino reaction for the synthesis of (S)-α-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fdbc98f156c02d699b1dd53bec19d10d https://doi.org/10.1016/j.tetlet.2013.01.080 Zobrazit plný text záznamu Full Text from ScienceDirect