Plant flavonol quercetin and isoflavone biochanin A differentially induce protection against oxidative stress and inflammation in ARPE-19 cells
| Autor: | Viivi H. Hassinen, Niina Saviranta, Reijo Karjalainen, Laura Veeroos, Lars Granlund, Kai Kaarniranta |
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| Rok vydání: | 2011 |
| Předmět: |
2. Zero hunger
0303 health sciences Programmed cell death biology Inflammation NF-κB Oxidative phosphorylation Pharmacology medicine.disease_cause Biochanin A 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Biochemistry 030221 ophthalmology & optometry biology.protein medicine heterocyclic compounds medicine.symptom Interleukin 6 Quercetin Oxidative stress 030304 developmental biology Food Science |
| Zdroj: | Food Research International. 44:109-113 |
| ISSN: | 0963-9969 |
| DOI: | 10.1016/j.foodres.2010.10.056 |
| Popis: | In this work, differential ability of plant flavonol quercetin and plant isoflavone biochanin A to modulate oxidative stress and inhibit inflammation-related responses was investigated using human retinal pigment epithelial cells (RPE) at gene expression level. Quercetin protected cells from oxidative stress-induced cell death, whereas biochanin A had no statistically significant protective effects. Quercetin reduced the expression of cytokines IL-6 and IL-1β in cells treated with H2O2, and expression levels of Nrf2 and HO-1 were increased by quercetin treatment suggesting protective function against oxidative stress. Our data indicate that quercetin may protect cells by inhibiting the production of pro-inflammatory factors such as IL-6, and by inducing the expression of ROS-catalyzing phase II proteins such as HO-1. Therefore, plant extracts rich in flavonol quercetin may be an interesting resource for functional food products and other foods targeted for reduced risks of age-related macular degeneration. |
| Databáze: | OpenAIRE |
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