Can MED-RT Summarization Support Missing Adverse Drug Reactions Discovery?

Autor: Ling Zheng, Joan Kapusnik-Uner
Rok vydání: 2020
Předmět:
Zdroj: BIBM
DOI: 10.1109/bibm49941.2020.9313523
Popis: Adverse drug reactions (ADRs) cause many hospitalizations and cases of mortality every year. A comprehensive list of potential ADRs for each drug is essential for assessing patients’ risks of ADRs when prescribing a medication. The Medication Reference Terminology (MED-RT) is a new drug terminology developed by the Veterans Health Administration. In this study, we examine whether the summarization of the chemical ingredients in MED-RT can support identifying knowledge gaps in lists of potential ADRs. MED-RT is a virtual terminology, which does not maintain drug and chemical ingredient concepts. Instead, it refers to external standard terminologies. In this study, we develop a new Summarization Network called Aggregate Virtual Ingredient Summarization Network (AVISN) for summarization of the MED-RT virtual Chemical Ingredients hierarchy. We demonstrate the use of the AVISN for discovering potential gaps for conditions associated with ADRs in First Databank’s Drug-Disease Contraindications knowledge base.
Databáze: OpenAIRE
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