Pleomorphic Sarcomas
| Autor: | Jean-Michel Coindre, Amandine Crombé, François Le Loarer, Daniel Pissaloux, Sofia Daniela Carvalho |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Leiomyosarcoma Pathology medicine.medical_specialty business.industry Myxofibrosarcoma Liposarcoma medicine.disease Undifferentiated Pleomorphic Sarcoma Pathology and Forensic Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis medicine Pleomorphism (microbiology) Immunohistochemistry Surgery Sarcoma business Rhabdomyosarcoma |
| Zdroj: | Surgical Pathology Clinics. 12:63-105 |
| ISSN: | 1875-9181 |
| DOI: | 10.1016/j.path.2018.10.004 |
| Popis: | This article focuses on pleomorphic sarcomas, which are malignant mesenchymal tumors with complex genetic background at the root of their morphologic pleomorphism. They are poorly differentiated tumors that may retain different lines of differentiation, sometimes correlating with clinicopathological or prognostic features. Accurate diagnosis in this group of tumors relies on adequate sampling due to their heterogeneity and assessment with both microscopy and large panels of immunohistochemistry. Molecular analyses have a limited role in their diagnosis as opposed to translocation-related sarcomas but may provide theranostic and important prognostic information in the future. |
| Databáze: | OpenAIRE |
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