| Autor: |
M. Manickavasagam, Ananth Pai, D. Barghavi, R.G. Balambika, V. Venkata Sampath, K. Sudheer Reddy, A. Vindhyavasini |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Annals of Oncology. 25:iv337 |
| ISSN: |
0923-7534 |
| DOI: |
10.1093/annonc/mdu339.38 |
| Popis: |
rd month using quantitative RT-PCR. Results were expressed as BCR-ABL/ABL ratio. Early molecular response (EMR) was defined as a transcript level ≤ 10%. Univariate and multivariate analysis (Linear regression) was performed to identify potential factors associated with the achievement of EMR. Univariate analysis (Linear regression) with RQPCR value at 3 rd month as dependent variable in relation to the other continuous variables was performed. Variables showing statistically significant association with the outcome (EMR at 3 rd month) at p < 0.05 were considered as candidate variables for inclusion in the multivariate model. Multivariate analysis (linear regression) was performed with the potential candidate variables as the co-variates. SPSS software version 17.0 was used for analysis. Results: The study population included 68 newly diagnosed patients of CP-CML, of which 55.88% (38) were males. The median age at diagnosis in our cohort was 46 years. According to Sokal risk stratification 55.88% (38), 33.82% (23) and10.29% (07) were in high, intermediate and low risk respectively. As per Hasford risk stratification score 25% (17), 61.76% (42), and 13.24% (09) were in high,intermediate and low risk respectively. EUTOS score stratified 58.82% (40) of patients as high risk and 41.18% (28) as low risk. 69.12% (47) of patients had b3a2 transcript and 30.88% (21) had b2a2 transcripts. 32.35% (22) achieved EMR at 3 rd month. In univariate analysis, spleen size (p= |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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