4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase
| Autor: | Helen Feilden, Anne Cleasby, Neil Taylor, Alan J. Wonacott, Paul W. Smith, Derek N. Evans, Steven L. Sollis, Peter D. Howes |
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| Rok vydání: | 1999 |
| Předmět: |
inorganic chemicals
Pharmacology chemistry.chemical_classification Molecular model biology Chemistry Stereochemistry medicine.drug_class organic chemicals Organic Chemistry Orthomyxoviridae Carboxamide General Medicine Sialidase biology.organism_classification Chemical synthesis Zanamivir Enzyme Enzyme inhibitor Drug Discovery medicine biology.protein medicine.drug |
| Zdroj: | European Journal of Medicinal Chemistry. 34:225-234 |
| ISSN: | 0223-5234 |
| Popis: | Two methods for the synthesis of 4-acetylamino benzoic acids substituted at the 3-position with imidazoles are described. Many of the compounds are inhibitors of influenza virus sialidases with levels of activity similar to the recently described 4-acetylamino-3-guanidino-benzoic acid (BANA 113). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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