Marine Natural Products as Antituberculosis Agents

Autor:	Jordan K. Zjawiony, Mark T. Hamann, Tony L. Perry, Xiaoyu Shen, Piotr Bartyzel, Khalid A. El Sayed
Rok vydání:	2000
Předmět:	Mycobacterium tuberculosis biology Chemistry medicine.drug_class Puupehenone Organic Chemistry Drug Discovery Antibiotics medicine biology.organism_classification Biochemistry Microbiology
Zdroj:	Tetrahedron. 56:949-953
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(99)01093-5
Popis:	In an attempt to characterize additional structural classes that could serve as lead antituberculosis agents, 48 structurally diverse marine-derived natural and semisynthetic compounds were examined for in vitro activity against Mycobacterium tuberculosis . Three new classes of compounds including C-19 hydroxy steroids, scalarin sesquiterpenoids and tetrabromo spirocyclohexadienylisoxazolines have been identified as having potential as leads for continued investigations as new antituberculosis agents. New additions to the established antituberculosis structural classes quinone-methide and peptide are also reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fdab32b74c606ed742f184c73b11f114 https://doi.org/10.1016/s0040-4020(99)01093-5 Zobrazit plný text záznamu Full Text from ScienceDirect