Theret/PTC Mutations Are Common in Sporadic Papillary Thyroid Carcinoma of Children and Young Adults1
| Autor: | Catherine A. Dinauer, Yvonne G. Lukes, Gary L. Francis, R. Michael Tuttle, Cydney Fenton, Diarmuid Nicholson |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases business.industry Endocrinology Diabetes and Metabolism Incidence (epidemiology) Biochemistry (medical) Clinical Biochemistry Thyroid medicine.disease Biochemistry Genetic determinism Papillary thyroid cancer Thyroid carcinoma Endocrinology medicine.anatomical_structure Internal medicine Genotype medicine Etiology Young adult business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 85:1170-1175 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.85.3.6472 |
| Popis: | The ret/PTC rearrangements (PTC-1, PTC-2, and PTC-3) are characteristic of papillary thyroid cancer (PTC). In adults, PTC-1 is common and may be associated with an aggressive clinical course. The incidence and significance of ret/PTC mutations are less well understood in children. We examined spontaneous PTC from 33 patients (23 females and 10 males) with a median age of 18 yr (range, 6–21 yr) and a median follow-up of 3.5 yr (range, 0–13.4 yr). The ret/PTC mutations were identified in 15 tumors (45%), including 8 PTC-1 (8 of 15, 53%), 2 PTC-2 (2 of 15, 13%), 2 PTC-3 (2 of 15, 13%), and 3 (3 of 15, 20%) combined PTC mutations (PTC-1 and PTC-2). This distribution is significantly different (P = 0.001, by χ2 analysis) from that reported for children with radiation-induced PTC. There was no correlation between the presence or type of ret/PTC mutation and patient age, tumor size, focality, extent of disease at diagnosis, or recurrence. We conclude that ret/PTC mutations are 1) common in sporadic childhood PTC... |
| Databáze: | OpenAIRE |
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