Mutagenic Activity of p-Toluenesulfonhydrazide
| Autor: | Blakey Dh, Bayley Jm, George R. Douglas, K.L. Maus, Nestmann Er |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
0301 basic medicine
endocrine system Mutation Salmonella endocrine system diseases 030102 biochemistry & molecular biology Chemistry Health Toxicology and Mutagenesis Chinese hamster ovary cell Public Health Environmental and Occupational Health food and beverages Mutagen 010501 environmental sciences Gene mutation Toxicology medicine.disease_cause 01 natural sciences Molecular biology In vitro 03 medical and health sciences In vivo medicine Microsome hormones hormone substitutes and hormone antagonists 0105 earth and related environmental sciences |
| Zdroj: | Toxicology and Industrial Health. 8:369-376 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/074823379200800603 |
| Popis: | Toluenesulfonhydrazide (TSH) is a high volume production chemical for which there is relatively little toxicological data. In this study, the mutagenic activity of TSH was determined in the Salmonella/mammalian microsome assay and the in vitro chromosomal aberration assay using Chinese hamster ovary cells. TSH induced gene mutations both with and without metabolic activation in the Salmonella/mammalian microsome assay but that it did not induce chromosomal aberrations in Chinese hamster ovary cells. The results of this study indicate that TSH is an in vitro mutagen and should be assessed for in vivo mutagenicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|