P211Vulnerable index detected by virtual histology intravascular ultrasound (VH-IVUS) in diseased coronary segments in patients with acute myocardial infarction and stable angina pectoris
| Autor: | R Shakhnovich, N Tagieva |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Physiology business.industry Histology medicine.disease_cause medicine.disease Vulnerable plaque Coronary artery disease Lesion Virtual histology intravascular ultrasound medicine.anatomical_structure Physiology (medical) Internal medicine Cardiology medicine In patient cardiovascular diseases Myocardial infarction medicine.symptom Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Cardiovascular Research. 103:S37.3-S37 |
| ISSN: | 1755-3245 0008-6363 |
| DOI: | 10.1093/cvr/cvu082.145 |
| Popis: | Title: Vulnerable index (VI) detected by virtual histology intravascular ultrasound (VH-IVUS) in diseased coronary segments in patients with acute myocardial infarction and stable angina pectoris. Purpose: The present study examined the relationship between the clinical presentation of coronary artery disease and the plaque characteristics of nonculprit segment assessed by virtual histology intravascular ultrasound (VH-IVUS). Objectives: The aim of this study was to investigate the difference of non-culprit lesion morphologies assessed by VH-IVUS between patients with acute myocardial infarction (AMI) and stable angina pectoris (SAP). Methods: In 38 consecutive AMI and 32 SAP patients the non-culprit artery was analyzed with VH-IVUS. We measured the 4 basic VH-IVUS coronary plaque components: fibrous, fibrofatty, dense calcium (DC), and necrotic core (NC). We calculated vulnerable index - NC/DC ratio. Results: We analyzed 130 plaques. AMI patients showed significantly higher ratio of dense calcium (9,27% +/- 7,5% versus 9.0% +/- 7,15%) and necrotic core plaque (25,4 % +/- 9% versus 23, % +/- 10%) compared with SAP patients. AMI group had greater vulnerable index (4,76 +/- 1,8 versus 4,03 +/- 2,6). VH-IVUS-derived thin-cap fibroatheroma (VH-TCFA) was more frequently observed in AMI patients compared with SA patients (40% versus 24%, p = 0.005). Conclusion: AMI patients presented higher prevalence of VH-TCFA in nonculprit segment. VH-IVUS analysis demonstrated that vulnerable index was associated with more vulnerable plaque components and was higher in AMI group. |
| Databáze: | OpenAIRE |
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