Discovery of tertiary aminoacids as dual PPARα/γ agonists-I

Autor:	Gary J. Grover, Narayanan Hariharan, Wei Wang, Dennis Farrelly, Jeon Yoon T, Fucheng Qu, Rajasree Golla, Zhengping Ma, Lisa Moore, Arthur M. Doweyko, Gamini Chandrasena, Pratik Devasthale, Denis E. Ryono, Lin Cheng, Chen Sean, Peter T. W. Cheng, Wei Sun, Ramakrishna Seethala, Paul G. Sleph, Hao Zhang
Rok vydání:	2007
Předmět:	chemistry.chemical_classification Agonist Stereochemistry medicine.drug_class Organic Chemistry Clinical Biochemistry Pharmaceutical Science Peroxisome proliferator-activated receptor Liquid phase Biochemistry Chemical synthesis chemistry Nuclear receptor Drug Discovery medicine Molecular Medicine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:2312-2316
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2007.01.060
Popis:	A novel series of potent dual agonists of PPARα and PPARγ, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure–activity relationships of this series of dual PPARα/γ agonists are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fd833e6d647f89a09342d5bb9c6b46a1 https://doi.org/10.1016/j.bmcl.2007.01.060 Zobrazit plný text záznamu Full Text from ScienceDirect