Cytoplasmic Tail Truncation Stabilizes S1-S2 Association and Enhances S Protein Incorporation into SARS-CoV-2 Pseudovirions
| Autor: | Lizhou Zhang, Nancy Hom, Amrita Ojha, Klaus N. Lovendahl, Huihui Mou, Kelly K. Lee, Hyeryun Choe |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Virology. 97 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.01650-22 |
| Popis: | Various forms of PVs have been used as tools to evaluate vaccine efficacy and study virus entry steps. When PV infectivity is inherently low, such as that of SARS-CoV-2, a CT-truncated version of the viral entry glycoprotein is widely used to enhance PV infectivity, but the mechanism underlying this enhanced PV infectivity has been unclear. |
| Databáze: | OpenAIRE |
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