Prise en charge de 145 cas de carcinomes à cellules de Merkel
| Autor: | Edward Yu, Antonin Levy, A. Assouline, Kurian Joseph, T. Miale, Dong Lian J, C. Krzisch, P Tai |
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| Rok vydání: | 2010 |
| Předmět: |
Oncology
Cancer Research Primary cutaneous neuroendocrine carcinoma medicine.medical_specialty Merkel cell carcinoma business.industry medicine.medical_treatment MEDLINE Salvage therapy Hematology General Medicine Disease medicine.disease Radiation therapy Internal medicine medicine Carcinoma Radiology Nuclear Medicine and imaging business Pathological |
| Zdroj: | Bulletin du Cancer. 97:1061-1066 |
| ISSN: | 0007-4551 |
| DOI: | 10.1684/bdc.2010.1166 |
| Popis: | Purpose Merkel cell carcinoma (MCC)/primary cutaneous neuroendocrine carcinoma is a rare and aggressive malignant tumor. Optimal therapeutic strategy has not yet been established. Patients and methods Management of 145 patients from five centres was analysed. These data included ages, pathological stages, disease sites, histological and treatment details. Cause-specific (CSS) and overall survivals (OS) were analyzed by the Log-rank and Kaplan-Meier methods. Results Median age was 78 years (47-95.2). We experienced 37 local, 37 regional and 15 distant relapses. In case of relapse, salvage therapy has been proposed whenever the general state of health condition of patient permitted it. Conclusion Our results for the treatment of relapse encourage multidisciplinary approach. Multicenter prospective trials are still needed to clarify and validate the optimal strategy. |
| Databáze: | OpenAIRE |
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