Synthesis of cell-laden alginate microgels with tunable compositions based on microfluidic pico-injection technique

Autor: Yizhe Zhang, Angelo Mao, David J. Mooney, David A. Weitz
Rok vydání: 2022
DOI: 10.1101/2022.01.09.475570
Popis: We report a microfluidic pico-injection-based approach for reliably generating monodisperse cell-laden alginate microgels whose composition can be tuned in situ through modulation of the cross-linker concentration. Separating the gelation from emulsification allows for a better control over the microgel size with a microfluidic drop-maker, and an instant adjustment of the microgel composition with a pico-injector.
Databáze: OpenAIRE