Human Cells Transformed In Vitro by Human Cytomegalovirus: Tumorigenicity in Athymic Nude Mice2

Autor:	John W. Kreider, Fred Rapp, Laszlo Geder
Rok vydání:	1977
Předmět:	Human cytomegalovirus Cancer Research Pathology medicine.medical_specialty medicine.diagnostic_test Congenital cytomegalovirus infection Biology medicine.disease Immunofluorescence Molecular biology Epithelium In vitro Transplantation medicine.anatomical_structure Oncology Antigen medicine Neoplasm
Zdroj:	JNCI: Journal of the National Cancer Institute. 58:1003-1009
ISSN:	1460-2105 0027-8874
DOI:	10.1093/jnci/58.4.1003
Popis:	Athymic nude mice were inoculated with human embryo lung cells transformed in vitro by human cytomegalovirus (CMV). Of the inoculated animals, 62% developed tumors after an average latent period of 19 days. The tumors were composed of small, polygonal cells with large nulei and scanty cytoplasm embedded in an abundant collagenous matrix. The cells were poorly differentiated but may have been of epithelial origin. Adjacent structures were rarely invaded. CMV-related intracellular and membrane antigens were detected by indirect and anticomplement immunofluorescence techniques in cells cultured in vitro from the tumors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fd4b3d6c04d74f3ae268d415bc4da50c https://doi.org/10.1093/jnci/58.4.1003 Zobrazit plný text záznamu