Transition-Metal-Catalyzed Nucleophilic Dearomatization of Electron-Deficient Heteroarenes

Autor:	Ying Xia, Fangdong Hu, Jie Jia
Rok vydání:	2021
Předmět:	Nucleophilic addition Transition metal Nucleophile Alkynylation Chemistry Organic Chemistry Enantioselective synthesis Combinatorial chemistry Catalysis
Zdroj:	Synthesis. 54:92-110
ISSN:	1437-210X 0039-7881
DOI:	10.1055/a-1577-7638
Popis:	In recent decades, transition-metal-catalyzed nucleophilic dearomatization of electron-deficient heteroarenes, such as pyridines, quinolines, isoquinolines and nitroindoles, has become a powerful method for accessing unsaturated heterocycles. This short review summarizes nucleophilic dearomatizations of electron-deficient hetero­arenes with carbon- and heteroatom-based nucleophiles via transition-metal catalysis. A significant number of functionalized heterocycles are obtained via this transformation. Importantly, many of these reactions are carried out in an enantioselective manner by means of asymmetric catalysis, providing a unique method for the construction of enantio­enriched heterocycles.1 Introduction2 Transition-Metal-Catalyzed Nucleophilic Dearomatization of Hetero­arenes via Alkynylation3 Transition-Metal-Catalyzed Nucleophilic Dearomatization of Heteroarenes­ via Arylation4 Transition-Metal-Catalyzed Nucleophilic Dearomatization of Heteroarenes­ with Other Nucleophiles5 Transition-Metal-Catalyzed Nucleophilic Dearomatization with Nucleophiles Formed In Situ6 Conclusion and Outlook
Databáze:	OpenAIRE
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