| Autor: |
Jun Zhi Wang, Xi Ming Yan, Nian Yu Huang, Ming Guo Liu, Ming Ruo Ding |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Advanced Materials Research. 918:32-35 |
| ISSN: |
1662-8985 |
| DOI: |
10.4028/www.scientific.net/amr.918.32 |
| Popis: |
Discovery of bioactive ingredients from plants and fungi is always the hot spots in medicinal chemistry. The trametenolic acid B was a bioactive lanostane-type triterpenoid inTrametes lactinea(Berk.) Pat. In this work, four semi-synthetic derivatives were synthesized, characterized and evaluated the anti-gastric cancer activities against HGC-27 cells with the aim of obtaining better anti-tumor agents. The compounds2aand3bpossessed good anti-proliferative effects under normal physiological conditions, and their anti-cancer effects increased as the pH decrease to 5.5 with the IC50of 17.55 and 10.63 μM, respectively. These compounds might be further developed as anti-gastric cancer drugs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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