Design, synthesis, docking and in vitro antifungal study of 1,2,4-triazole hybrids of 2-(aryloxy)quinolines
| Autor: | Sheshagiri R. Dixit, Shilpa M. Somagond, Pramod P. Kattimani, Shrinivas D. Joshi, Ravindra R. Kamble |
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| Rok vydání: | 2017 |
| Předmět: |
Antifungal
biology 010405 organic chemistry medicine.drug_class Organic Chemistry Quinoline 1 2 4-Triazole 010402 general chemistry 01 natural sciences Combinatorial chemistry In vitro 0104 chemical sciences chemistry.chemical_compound chemistry Design synthesis Docking (molecular) Dihydrofolate reductase medicine biology.protein |
| Zdroj: | Heterocyclic Communications. 23:317-324 |
| ISSN: | 2191-0197 0793-0283 |
| Popis: | Substituted quinolines containing a 1,2,4-triazole moiety were synthesized using reported methods. The molecular docking studies support the experimental results that these compounds are active against A. fumigatus and C. albicans where N-myristoyl transferase (NMT) and dihydrofolate reductase (DHFR), respectively, are the target enzymes. The analogues that contain methoxy and chloro substituents exhibit the best antifungal activity. |
| Databáze: | OpenAIRE |
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