The effect of pulsatile perfusion on cerebral blood flow during profound hypothermia with total circulatory arrest: A randomized, prospective, double-blind study
| Autor: | Ryoko Tabata, Atsumi Mori, Shoji Watarida, Shuichi Matsuno, Shoichiro Shiraishi, Takehisa Nojima, Masahiko Onoe, Takaaki Sugita, Yasuhiko Nakajima |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pulmonary and Respiratory Medicine
Resuscitation biology business.industry Fissipedia Pulsatile flow Hemodynamics biology.organism_classification law.invention Cerebral blood flow law Anesthesia Circulatory system Cardiopulmonary bypass Medicine Surgery Cardiology and Cardiovascular Medicine business Perfusion |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 108:119-125 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(94)70227-6 |
| Popis: | In 39 mongrel dogs, regional cerebral blood flow was measured during pulsatile and nonpulsatile deep hypothermic cardiopulmonary bypass with total circulatory arrest. Total circulatory arrest was performed at 20° C cerebral temperature for 40 minutes in 15 dogs, 60 minutes in 12 dogs, and 80 minutes in 12 dogs. Cerebral blood flow in both groups decreased as cerebral temperature fell and there was no significant difference in cerebral blood flow between the two groups during the cooling period. After circulatory arrest for 40 minutes, as cerebral temperature increased to 35° C, cerebral blood flow in both groups recovered to values as high as the respective initial values, which were measured just after the beginning of cardiopulmonary bypass for cooling (102.5% ± 10.2% in the pulsatile group and 97.2% ± 12.6% in the nonpulsatile group). After circulatory arrest for 60 minutes, cerebral blood flow in the pulsatile group increased to 141.8% ± 16.1% of its initial value when the cerebral temperature became 35° C, but it remained significantly lower (64.5% ± 9.2%) in the nonpulsatile group ( p |
| Databáze: | OpenAIRE |
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