| Autor: |
Makoto Arisue, Toshiyuki Shibata, Yasuhito Minamida, Katsutoshi Ito, Hiroki Nagayasu, Masaya Yamamoto, J. Hino, Yasuhiko Tabata, Toshiyuki Akazawa, Junichi Tazaki, Masaru Murata |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Key Engineering Materials. :50-54 |
| ISSN: |
1662-9795 |
| DOI: |
10.4028/www.scientific.net/kem.529-530.50 |
| Popis: |
We previously reported functionally graded hydroxyapatite (fg-HAp) with the characteristics of blood permeability into the bulk and osteoinduction by adding low dose of bone morphogenetic protein-2 (BMP-2). In this study, we evaluated the bioactivity of the obtained dense HAp bodies in a simulated body fluid (SBF) and the osteoinductive activity with or without SBF treatment in vivo. The fg-HApSBF was prepared by immersing the fg-HAp in the SBF solution at 14 days and the surface structure was observed by SEM. The fg-HApSBF showed fine bone-like crystal on the surface of the HAp. Ectopic bone formation occurred in the fg-HAp/BMP-2 (1.0, 0.5μg) system at 3 weeks, while only in the fg-HApSBF/BMP-2 (1.0μg), bone induction was found. The histological finding showed body fluid permeation into the fg-HApSBF bulk and bone formation were obserbed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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