Phylogenetic analysis of clinical mumps virus isolates from vaccinated and non-vaccinated patients with mumps during an outbreak, Switzerland 1998-2000

Autor:	Kathrin Mühlemann, Selja E. Capaul, Meri Gorgievski Hrisoho, Silvia Utz, Jean-Luc Richard, Hans C Matter
Rok vydání:	2004
Předmět:	biology Paramyxoviridae business.industry Outbreak Mumps virus biology.organism_classification medicine.disease_cause Virology Virus Microbiology Vaccination Infectious Diseases Medicine Viral disease Rubulavirus business Mononegavirales
Zdroj:	Journal of Medical Virology. 73:91-96
ISSN:	0146-6615
DOI:	10.1002/jmv.20064
Popis:	During the past decade mumps outbreaks have occurred in several European countries with universal vaccination programs probably due to poor efficacy of the Rubini vaccine strain. However, the evolution of vaccine escape mutants has also been considered. A phylogenetic analysis was undertaken on 69 clinical mumps isolates obtained from 39 vaccinated and 22 non-vaccinated mumps cases (and six cases with unknown vaccination status) during an outbreak in 1998–2000. Two major strain clusters (SWI-H, SWI-C) with two subgroups each (SWI-H1/2, SWI-C1/2) were identified, which belonged to genotypes C and H. No association between viral clusters and vaccination status or a specific vaccine strain (Jeryl-Lynn or Rubini) was found. Cluster SWI-C1 occurred more frequently in the Western part of Switzerland (P
Databáze:	OpenAIRE
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