| Autor: |
Frederieke A.J. Gigase, Nina M. Molenaar, Roy D. Missall, Anna-Sophie Rommel, Whitney Lieb, Erona Ibroci, Sophie Ohrn, Jezelle Lynch, Florian Krammer, Rachel Brody, Rebecca H. Jessel, Rhoda S. Sperling, Corina Lesseur, Francesco Callipari, Romeo R. Galang, Margaret C. Snead, Teresa Janevic, Joanne Stone, Elizabeth A. Howell, Jia Chen, Victor J.M. Pop, Siobhan M. Dolan, Veerle Bergink, Lotje D. De Witte |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Objective: Dysregulation of the immune system during pregnancy is associated with adverse pregnancy outcomes. Recent studies report cytokine changes during the acute phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We examine whether there is a lasting association between SARS-CoV-2 infection during pregnancy and peripheral blood cytokine levels. Study design: We conducted a case-control study at the Mount Sinai health system in NYC including 100 SARS-CoV-2 IgG antibody positive people matched to 100 SARS-CoV-2 IgG antibody negative people on age, race/ethnicity, parity, and insurance status. Blood samples were collected at a median gestational age of 34 weeks. Levels of 14 cytokines were measured. Results: Individual cytokine levels and cytokine cluster Eigenvalues did not differ significantly between groups, indicating no persisting maternal cytokine changes after SARS-CoV-2 infection during pregnancy. Conclusion: Our findings suggest that the acute inflammatory response after SARS-CoV-2 infection may be restored to normal values during pregnancy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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