Towards the total synthesis of tonantzitlolone––preparation of key fragments and the complete carbon backbone

Autor:	Rüdiger Wittenberg, Christian Beier, Gerald Dräger, Gerhard Jas, Holger Monenschein, Christian Jasper, Andreas Kirschning
Rok vydání:	2004
Předmět:	Chemistry Stereochemistry Organic Chemistry Total synthesis chemistry.chemical_element Biochemistry Formylation Chromium Aldol reaction Tonantzitlolone Drug Discovery Reformatsky reaction Polymer supported reagents Carbon
Zdroj:	Tetrahedron Letters. 45:4457-4460
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2004.04.056
Popis:	The first synthetic advances towards the novel diterpenoid tonantzitlolone 1 are described. The key steps in the synthesis involve a chromium(II) Reformatsky reaction, a diastereoselective C 1 extension and an expeditious aldol coupling step of two advanced precursors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fd09530abbbbb4ae0f7e7b8e8f13db85 https://doi.org/10.1016/j.tetlet.2004.04.056 Zobrazit plný text záznamu Full Text from ScienceDirect