Synthesis of gentamicin-grafted-chitosan with improved solubility and antibacterial activity
| Autor: | Qianqian Ouyang, Zhong Qingkun, Tao Wang, Tingting Yan, Puwang Li, Ziming Yang, Sidong Li, Dong-Ying Zhang, Chengpeng Li, Qingxia Zhao |
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| Rok vydání: | 2019 |
| Předmět: |
Aqueous solution
Polymers and Plastics General Chemical Engineering 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Antimicrobial 01 natural sciences Biochemistry 0104 chemical sciences Chitosan chemistry.chemical_compound Membrane chemistry Materials Chemistry medicine Environmental Chemistry Degradation (geology) Gentamicin Solubility 0210 nano-technology Antibacterial activity Nuclear chemistry medicine.drug |
| Zdroj: | Reactive and Functional Polymers. 137:38-45 |
| ISSN: | 1381-5148 |
| DOI: | 10.1016/j.reactfunctpolym.2019.01.013 |
| Popis: | Due to superior properties, chitosan (CS) has been widely applied in health field. However its acid-solubility and poor antimicrobial activity compromise its safety and applications, respectively. To enhance its water-solubility and antimicrobial activity, gentamicin-grafted-chitosan (GT-CS) is synthesized for the first time, which is then confirmed by various characteristic methods and the graft ratio for gentamicin is about 22.1%. Particularly, it is the first study, disclosing there are degradation and crosslinking involved simultaneously during CS oxidation. Furthermore, GT-CS shows greatly improved water solubility (10.0w%). Compared to CS, the antibacterial activity of GT-CS is improved significantly, approaching the pure gentamicin. It should be noted that the antimicrobic mechanism may not be the target-specific interactions but the nonspecific interactions with the bacterial membrane as shown by scanning electron microscope. To sum up, GT-CS is a superior antimicrobial with good solubility. |
| Databáze: | OpenAIRE |
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