Total syntheses of close analogues of the immunosuppressant FK506

Autor:	Stuart Donald Jones, Murdoch Robert, Golec Julian M C, Roger John Gillespie, Mark Batchelor, Hedgecock Charles John Robert
Rok vydání:	1994
Předmět:	chemistry.chemical_classification Chemistry Stereochemistry Organic Chemistry Total synthesis Biochemistry Aldehyde chemistry.chemical_compound Residue (chemistry) Drug Discovery Wittig reaction Lactam Phenyl group Stereoselectivity Lactone
Zdroj:	Tetrahedron. 50:809-826
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)80796-1
Popis:	The total synthesis of an analogue of FK506, in which the substituted cyclohexyl residue at C28 has been replaced by a phenyl group, is described. This synthesis demonstrates (i) the successful application of new methodology for the introduction of the masked tricarbonyl grouping (C8-C10), and (ii) new synthetic routes to the (C10-C19) and (C22-C26) regions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fcf2e783606572cdb490baaeaf2d7684 https://doi.org/10.1016/s0040-4020(01)80796-1 Zobrazit plný text záznamu