The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats
| Autor: | Şaban Cem Sezen, Işın Güneş, Hakan Boyunaga, Mustafa Arslan, Aycan Ozdemirkan, Ayşegül Küçük, Volkan Şıvgın, Aydın Tunçay |
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| Rok vydání: | 2020 |
| Předmět: |
Cerium oxide
Biophysics Pharmaceutical Science chemistry.chemical_element Bioengineering 02 engineering and technology Lung injury 010402 general chemistry medicine.disease_cause 01 natural sciences Oxygen Sevoflurane Biomaterials Drug Discovery medicine Organic Chemistry General Medicine 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Cerium Clamp chemistry Anesthesia 0210 nano-technology Reperfusion injury Oxidative stress medicine.drug |
| Zdroj: | International Journal of Nanomedicine. 15:7481-7489 |
| ISSN: | 1178-2013 |
| DOI: | 10.2147/ijn.s263001 |
| Popis: | Introduction We aimed to investigate the effects of cerium oxide, applied before the sevoflurane anesthesia, on lung tissue in rats with lower extremity ischemia-reperfusion (IR). Materials and methods A total of 30 rats were randomly divided into five groups as; control (C), IR, cerium oxide-IR (CO-IR), IR-sevoflurane (IRS), and cerium oxide-IR-sevoflurane (CO-IRS). In the CO-IR group, 30 minutes after the injection of cerium oxide (0.5 mg/kg, intraperitoneal (i.p)), an atraumatic microvascular clamp was placed on the infrarenal abdominal aorta for 120 minutes. Then, the clamp was removed and reperfused for 120 minutes. Sevoflurane was applied in 100% oxygen at a rate of 2.3% at 4 L/min during IR. The blood samples were taken for biochemical analysis and the lung tissue samples were taken for histological analysis. Results Neutrophil infiltration/aggregation was significantly higher in the IR group than in the C and CO-IRS groups. The alveolar wall thickness and total lung injury scores were significantly higher in the IR group than in the C, IRS, CO-IR and CO-IRS groups. Discussion We determined that the administration of 0.5 mg/kg dose of cerium oxide with sevoflurane reduces the oxidative stress and corrects IR-related damage in lung tissue. Our results show that the administration of cerium oxide before IR and the administration of sevoflurane during IR have a protective effect in rats. |
| Databáze: | OpenAIRE |
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