| Autor: |
Pierre Ellul, Anna Maruani, Valérie Vantalon, Elise Humeau, Anouck Amestoy, Andrea Anchordoqui, Paola Atzori, Jean-Marc Baleyte, Safiyah Benmansour, Olivier Bonnot, Manuel Bouvard, Ariane Cartigny, Nathalie Coulon, Romain Coutelle, David Da Fonseca, Caroline Demily, Marion Givaudan, Fanny Gollier-Briant, Fabian Guénolé, Andrea Koch, Marion Leboyer, Aline Lefebvre, Florian Lejuste, Charlotte Levy, Eugénie Mendes, Natalia Robert, Carmen M Schroder, Mario Speranza, Elodie Zante, Hugo Peyre, Michelle Rosenzwajg, David Klatzmann, nicolas tchitchek, Richard DELORME |
| Rok vydání: |
2023 |
| DOI: |
10.21203/rs.3.rs-2623908/v1 |
| Popis: |
Background Autism spectrum disorders (ASD) are neurodevelopmental disorders characterised by deficits in social communication or interaction and repetitive behaviours. Maternal immune activation (MIA) during the mid-pregnancy is a known risk factor for ASD. Although reported in 15% of affected individuals, little is known about the specificity of their clinical profiles. Adaptive skills represent a holistic approach to a person's competencies and reflect specifically in autism, their strengths and difficulties. Methods In this study, we hypothesised that individual with ASD with a history of MIA (MIA+) could be more severely socio-adaptively impaired than those without MIA during pregnancy (MIA−). To answer this question, we considered two independent cohorts of individuals with ASD (PARIS study and FACE ASD) screened for pregnancy history, and used a supervised and unsupervised statistical approach. Results We included 295 mother-child dyads with 14% of them with MIA+. We found that ASD-MIA+ individuals displayed more severe maladaptive behaviors, specifically in their socialization abilities. MIA+ directly influenced individual's socio-adaptive skills, independent of other covariates, including ASD severity. Interestingly, MIA+ may affected persistently the socio-adaptive behavioral trajectories of individuals with ASD. Limitations : The current study has a retrospective design with possible recall bias regarding the MIA event and, even if pooled from two cohorts, has a relatively small population. In addition, we were limited by the number of covariables available potentially impacted socio-adaptive behaviors. Larger prospective study with additional dimensions related to ASD is needed to confirm our results Conclusions Specific pathophysiological pathways may explain these clinical peculiarities of ASD- MIA+ individuals, and may open the way to new perspectives in deciphering the phenotypic complexity of autism and for the development of specific immunomodulatory strategies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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