Potential Diagnostic Value Of Combining Inflammatory Cell Ratios With Carcinoembryonic Antigen For Colorectal Cancer
| Autor: | Xinxin Li, Ling-Yu Chu, Fei-Ran Zhang, Juntian Chen, Wei Li, Yiteng Huang, Dongming Guo |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Colorectal cancer Lymph node metastasis Gastroenterology 03 medical and health sciences 0302 clinical medicine Carcinoembryonic antigen Internal medicine Inflammatory cell medicine Stage (cooking) neoplasms biology Receiver operating characteristic business.industry Area under the curve medicine.disease digestive system diseases body regions 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cohort biology.protein business |
| Zdroj: | Cancer Management and Research. 11:9631-9640 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s222756 |
| Popis: | Purpose To evaluate the diagnostic value of combining the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) or lymphocyte-monocyte ratio (LMR) with carcinoembryonic antigen (CEA) in patients with colorectal cancer (CRC). Patients and methods The diagnostic performance of inflammatory makers and CEA was evaluated in cohort 1 (664 patients with CRC, 336 patients with colorectal polyps and 664 healthy controls) and validated in cohort 2 (87 patients with CRC and 87 healthy controls) by using receiver operating characteristic curve analysis. Results In cohort 1, the NLR, PLR and CEA levels were significantly higher, while the LMR was markedly lower in patients with CRC than in healthy controls. The PLR and LMR were significantly associated with invasion depth and lymph node metastasis. Moreover, significant differences in the PLR and LMR were observed between patients with stage I/II CRC and healthy or polyp controls and those with stage III/IV CRC. Using the NLR, PLR or LMR with CEA resulted in a significantly larger area under the curve (AUC) than any of them used alone. Combining the PLR and LMR with CEA exhibited the best diagnostic value for CRC (AUC=0.892). The AUCs of this combination were 0.864 and 0.783 for distinguishing stage I/II CRC from healthy and polyp controls, respectively. When we used the same cut-off values to assess the diagnostic ability of these markers in cohort 2, similar results were observed, and the PLR, LMR and CEA combination also showed the highest accuracy (AUC=0.936). Conclusion Combining inflammatory cell ratios with CEA could improve the diagnostic efficacy for CRC patients. The combination of the PLR and LMR with CEA might be a valuable indicator in the early detection and monitoring of CRC patients. |
| Databáze: | OpenAIRE |
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