Complex of tris(2-hydroxyethyl)amine with zinc bis(2-methylphenoxyacetate) as an inhibitor of the acid lipase of the aortic intima
| Autor: | I. V. Zhigacheva, P. A. Storozhenko, M. M. Rasulov |
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| Rok vydání: | 2021 |
| Předmět: |
Tris
chemistry.chemical_classification medicine.medical_specialty Aorta Aqueous solution Cholesterol chemistry.chemical_element General Chemistry Zinc chemistry.chemical_compound Endocrinology Enzyme chemistry Internal medicine medicine.artery cardiovascular system medicine Amine gas treating Acid lipase |
| Zdroj: | Russian Chemical Bulletin. 70:1418-1420 |
| ISSN: | 1573-9171 1066-5285 |
| Popis: | The previously unknown ability of Zitrimin, the complex of tris(2-hydroxyethyl)amine with zinc(ii) bis(2-methylphenoxyacetate), to affect the activity of acid lipase of the aortic intima was studied. Daily administration of an aqueous solution of the tris(2-hydroxyethyl)amine complex with zinc bis(2-methylphenoxyacetate) in a dose of 10 mg kg−1 for 3 months to rabbilts with experimental atherosclerosis was found to decrease the cholesterol and total lipid levels in the aortic tissue and to decrease the degree of aortic damage with atherosclerotic plaques. According to the results of enzymatic analysis, development of atherosclerosis is accompanied by 68% increase in the activity of acid lipase in the intima of the aorta compared to the control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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