| Popis: |
Allergen immunotherapy is the only treatment that can treat the cause of the allergy. Rapid desensitization (or ultrarush) allow saving time. However, there are the same tolerance than classic immunotherapy ? We have made a prospective study in the department of pneumology in military hospital of Tunisia. We collected 46 children for a period of one year and falling comparing the safety of sublingual immunotherapy Ultra-Rush (n = 28) with the classical subcutaneous immunotherapy (n = 18). The mean age was 8.21 years ( 3-13 years). We had 32 (69%) male and 14 (30%) female. A family atopy was noted in 22 (47%). Active smoking in 1case (2%). 19 patients (41%) had side effects: local for subcutaneous such as erythema in 3 cases (16%), a papule in 2 cases (11%), induration in 1 case (5% ), a subcutaneous nodule in 1case (5%) and no effect in10 cases (55%).For the sublingual : an oral pruritus in 7 cases (25%), lips edema in 2 cases (7%), abdominal pain in 2 case (7%). The systemic effects was found in 11 cases and it was benin such as a general pruritus in 3 cases, 2 cases conjunctivitis, rhinitis in 4 case,a hives in 2 cases, no asthma attack, no edema of Quink or anaphylactic reaction were noted ; 10 case (35%) with the sublingual treatment and only 1 case (5% ) case with subcutaneously treatment. Our study showed an excellent tolerability of sublingual Ultra-Rush, comparable to subcutaneous and studies published in the literature. |
