ChemInform Abstract: Synthesis and Application of Atropisomeric Dihydrobenzofuran-Based Bisphosphine (BICMAP)

Autor:	Shunsuke Oishi, Takashi Mino, Yoshiaki Naruse, Masami Sakamoto, Tsutomu Fujita, Shohei Kobayashi
Rok vydání:	2009
Předmět:	chemistry.chemical_compound Aniline chemistry Ligand Aryl medicine Organic chemistry General Medicine Chiral stationary phase Chloride High-performance liquid chromatography Amination medicine.drug
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200934085
Popis:	A new atropisomeric dihydrobenzofuran-based bisphosphine ligand 1 was easily prepared from 1,4-dibromo-2-fluorobenzene. This racemic bisphosphine (±)-1 was used as a ligand for the palladium-catalyzed Suzuki–Miyaura reaction of aryl chloride with arylboronic acids and Hartwig–Buchwald amination of aryl bromides with aniline derivatives. The optical resolution of (±)-1 was also carried out by HPLC with a chiral stationary phase column.
Databáze:	OpenAIRE
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