A new alkaloid with cytotoxic activity from Fritillaria thunbergii Miq

Autor:	Wang Jianzhong, Cui-lin He, You-ran Liu, Xing-hong Liu, Chen Donglin
Rok vydání:	2021
Předmět:	biology Cell growth Chemistry Stereochemistry Alkaloid Organic Chemistry Fritillaria Biological activity Plant Science biology.organism_classification Biochemistry Fritillaria thunbergii In vitro Analytical Chemistry Cytotoxic T cell Veratramine
Zdroj:	Natural Product Research. 36:5297-5303
ISSN:	1478-6427 1478-6419
DOI:	10.1080/14786419.2021.1933970
Popis:	A new alkaloid named zhebeisine (1), together with four known compounds, eduardine (2), zhebeirine (3), isoverticine (4), and verticine (5), was isolated from the bulbs of Fritillaria thunbergii Miq. The structure of the new compound was elucidated on the basis of extensive spectroscopic methods and the in vitro biological activities of it were evaluated as well. Compound 1 features a veratramine skeleton with a rare 6/6/5/6/6/6 fused-ring system, representing the first reported veratramine-type alkaloid with a new oxazinane ring (ring-F) in Fritillaria genus. The cytotoxic activities study revealed that compound 1 inhibited the cell proliferation of HT29 and DLD1 (IC50 values of 25.1 and 48.8 µM, respectively) and also induced apoptosis of the above-mentioned two cancer cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fcc44a6459c3fed3e710b9ad7ed802dd https://doi.org/10.1080/14786419.2021.1933970 Zobrazit plný text záznamu