Pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in adult goats

Autor: Samanta Waxman, M. L. de Vicente, Casilda Rodríguez, M. I. San Andrés, M. D. San Andrés, F. González
Rok vydání: 2002
Předmět:
Zdroj: Journal of Veterinary Pharmacology and Therapeutics. 24:375-378
ISSN: 0140-7783
DOI: 10.1046/j.1365-2885.2001.00357.x
Popis: The pharmacokinetic behavior of marbofloxacin was studied in goats after single-dose intravenous (i.v.) and intramuscular (i.m.) administrations of 2 mg/kg bodyweight. Drug concentration in plasma was determined by high performance liquid chromatography (HPLC) and the data collected were subjected to compartmental and noncompartmental kinetic analysis. This compound presented a relatively high volume of distribution (Vss=1.31 L/kg), which suggests good tissue penetration, and a total body clearance (Cl) of 0.23 L/kg small middle doth, which is related to a long elimination half-life (t1/2beta=7.18 h and 6.70 h i.v. and i.m., respectively). Pharmacokinetic parameters were not significantly different between both routes of administration. Marbofloxacin was rapidly absorbed after i.m. administration (Tmax=0.9 h) and had high bioavailability (F=100.74%).
Databáze: OpenAIRE