In-vitroAnthelmintic and Antioxidant Activity ofHelicteres isoraLinn. Fruit Extracts
Autor: | Shashikant C. Dhawale, Prasad G. Jamkhande, Mahesh Bandappa Manke, Sanjay S. Pekamwar, Dasrao A. Patil |
---|---|
Rok vydání: | 2015 |
Předmět: |
Pharmacology
Antioxidant Helicteres isora Traditional medicine biology DPPH medicine.medical_treatment Plant Science Toxicology Ascorbic acid biology.organism_classification Agricultural and Biological Sciences (miscellaneous) chemistry.chemical_compound Complementary and alternative medicine chemistry Drug Discovery medicine Organic chemistry Petroleum ether Methanol Anthelmintic Hydrogen peroxide medicine.drug |
Zdroj: | Journal of Biologically Active Products from Nature. 5:18-24 |
ISSN: | 2231-1874 2231-1866 |
Popis: | In-vitro anthelmintic activity of methanol and petroleum ether extracts of Helicteres isora fruits were determined by the evaluation of time for paralysis and death (min.) against Indian earthworms Pheretima posthuma. Various concentrations of extracts were tested in the bioassay (10, 20, and 50 mg/ml). Albendazole at concentration 20 mg/ml was included as standard reference while normal saline (0.9 % NaCl) solution as control. Antioxidant activity was determined by 2, 2-diphenyl-1-picryl hydrazyl (DPPH) and Hydrogen peroxide (H2O2) radicals scavenging assays. The both methanol and petroleum ether extracts showed dose dependent anthelmintic activity. The DPPH free radical scavenging activity was obtained with the methanol extract (IC50 42.95 µg/ml), while petroleum ether extract showed less free radical scavenging activity (IC50 89.81 μg/ml) as compared to standard ascorbic acid (IC50 23.75 µg/ml). Hydrogen peroxide decomposition activity of methanol and petroleum ether extracts were showed in a c... |
Databáze: | OpenAIRE |
Externí odkaz: |