Antibacterial Activity of a Chitosan Derivative Obtained in the Absence of a Solvent
| Autor: | Josy Anteveli Osajima, Idglan Sá de Lima, Humberto Medeiros Barreto, Luizângela Reis Osório, Edson Cavalcanti da Silva Filho |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Mechanical Engineering Chemical structure Imine Chemical modification 020101 civil engineering 02 engineering and technology Condensed Matter Physics 01 natural sciences 010406 physical chemistry 0201 civil engineering 0104 chemical sciences Solvent Chitosan chemistry.chemical_compound chemistry Mechanics of Materials Organic chemistry General Materials Science Fourier transform infrared spectroscopy Antibacterial activity Derivative (chemistry) |
| Zdroj: | Materials Science Forum. 869:869-873 |
| ISSN: | 1662-9752 |
| Popis: | A novel chitosan derivative was prepared through direct reaction of pure chitosan with acetylacetone in the absence of a solvent, and it was characterized by elemental analysis, Fourier transform infrared spectrometry (FTIR), and 13C Nuclear Magnetic Ressonance (NMR) spectroscopy. Moreover, the antibacterial properties of the new biomaterial were tested by the direct contact method against multi-drug resistant strains of Staphylococcus aureus and Escherichia coli. The results from the characterization were consistent with the modification of the chemical structure made. The new derivative showed a better antibacterial activity than raw chitosan against E. coli strains, indicating that incorporation of imine link (Schiff base) enhanced its antibacterial activity against Gram-negative bacterium. On the contrary, this chemical change did not decrease its antibacterial activity against Gram-positive bacterium. |
| Databáze: | OpenAIRE |
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