Cascade recyclization of N-arylitaconimides as a new approach to the synthesis of polyfunctional octahydroquinolines

Autor:	Mikhail Yu. Krysin, Yevgeniya A. Kosheleva, Khidmet S. Shikhaliev, Andrei Yu. Potapov, Yurii A. Kovygin, Dmitriy Yu. Vandyshev, Irina V. Ledenyova
Rok vydání:	2019
Předmět:	010405 organic chemistry Cascade Chemistry Intramolecular force Organic Chemistry Regioselectivity Domino process New variant 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences
Zdroj:	Chemistry of Heterocyclic Compounds. 55:748-754
ISSN:	1573-8353 0009-3122
Popis:	A new variant of Hantzsch reaction was developed for the synthesis of 1,2,3,4,5,6,7,8-octahydroquinolines on the basis of regioselective cascade recyclization of N-arylitaconimides in reactions with 3-aminocyclohex-2-enones. The mechanism of this domino process included С-nucleophilic addition of enaminone to the activated multiple bond of itaconimide and intramolecular transamidation with simultaneous recyclization of the intermediate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fcb6c776ca7448bd05e3732dd7d58af8 https://doi.org/10.1007/s10593-019-02530-5 Zobrazit plný text záznamu Full text from SpringerLink