Dynamic assessment of RBC-transfusion dependency improves the prognostic value of the revised-IPSS in MDS patients
| Autor: | Devendra K Hiwase, Rakchha Chhetri, Ulrich Germing, Ian D. Lewis, Peter G Bardy, Chi-Hung Hui, David M. Ross, Shriram V. Nath, Monika M Kutyna, Peter B. Harrison, L Amilia Wee, L. Bik To, John V. Reynolds, Nicholas Wickham, Deepak Singhal, James X Gray, Corinna Strupp |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty Cytopenia Multivariate analysis business.industry Proportional hazards model Incidence (epidemiology) Myelodysplastic syndromes Regression analysis Hematology medicine.disease 03 medical and health sciences 0302 clinical medicine International Prognostic Scoring System 030220 oncology & carcinogenesis Internal medicine medicine business 030215 immunology Cause of death |
| Zdroj: | American Journal of Hematology. 92:508-514 |
| ISSN: | 0361-8609 |
| DOI: | 10.1002/ajh.24704 |
| Popis: | RBC-transfusion dependency (RBC-TD) is an independent prognostic factor for poor overall survival (OS) in the WHO classification-based prognostic scoring system (WPSS) for MDS patients. However, WPSS did not include cytopenia, whereas revised International Prognostic Scoring System (IPSS-R) did not include RBC-TD. Thus, neither of these prognostic scoring systems incorporates both cytopenia and RBC-TD. We aimed to test whether RBC-TD adds prognostic value to the IPSS-R. We analyzed MDS patients not treated with disease-modifying therapy, and enrolled in SA-MDS Registry (derivation cohort; n = 295) and Dusseldorf registry (Germany; validation cohort; n = 113) using time-dependent Cox proportional regression and serial landmark analyses. In the derivation cohort, RBC-TD patients had inferior OS compared to RBC transfusion-independent (RBC-TI) patients (P |
| Databáze: | OpenAIRE |
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