Comparative Evaluation of Porous Carriers for Dissolution Improvement of BCS Class II Drug
| Autor: | Ashish Yadav, P.R. Patel, Shailesh Koradia, Kautuk Shah, Ashok Mahajan, Falgun Mehta |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
Materials science media_common.quotation_subject 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Class (biology) Comparative evaluation 03 medical and health sciences 0302 clinical medicine Chemical engineering medicine Pharmacology (medical) Ziprasidone 0210 nano-technology Pharmacology Toxicology and Pharmaceutics (miscellaneous) Dissolution media_common medicine.drug |
| Zdroj: | Research Journal of Pharmacy and Technology. :1899-1904 |
| ISSN: | 0974-360X 0974-3618 |
| Popis: | The objective of present investigation was comparison of porous carriers to increase the dissolution properties of BCS class II drug Ziprasidone. Solvent evaporation method was used for the adsorption of ziprasidone on various porous carriers. Three different porous carriers namely Florite, Neusilin US2, Sylysia 350 were used in the study. Prepared microparticles were characterised for invitro drug release, SEM, XRD and DSC. The optimized formulation containing ziprasidone: florite microparticles had high drug release (94.88% in 45 min) than plain ziprasidone tablets (21.13% in 45 min) which is due to increase in surface area and decrease in crystallinity of drug after adsorption onto porous carrier. |
| Databáze: | OpenAIRE |
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