Facile synthesis of novel fluorine containing pyrazole based thiazole derivatives and evaluation of antimicrobial activity
| Autor: | Nisheeth C. Desai, H. V. Vaghani, H. M. Satodiya, K. M. Rajpara, V. V. Joshi |
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| Rok vydání: | 2012 |
| Předmět: |
biology
Stereochemistry Organic Chemistry Aspergillus niger Pyrazole biology.organism_classification medicine.disease_cause Antimicrobial Biochemistry Inorganic Chemistry chemistry.chemical_compound chemistry medicine Environmental Chemistry Physical and Theoretical Chemistry Candida albicans Thiazole Antibacterial activity Escherichia coli Aspergillus clavatus |
| Zdroj: | Journal of Fluorine Chemistry. 142:67-78 |
| ISSN: | 0022-1139 |
| Popis: | A series of compounds 2-(5-(3-(4-fluorophenyl)-1-phenyl-1 H -pyrazol-4-yl)-3-(aryl)-4,5-dihydro-1 H -pyrazol-1-yl)thiazol-4(5 H )-ones ( 4a – q ) were synthesized and structures of these compounds were elucidated by spectral (IR, 1 H NMR, 13 C NMR, mass spectra) analysis. Synthesized compounds were screened for in vitro antibacterial activity against the representative panel of Gram-positive ( Staphylococcus aureus , Streptococcus pyogenes ) and Gram-negative ( Escherichia coli , Pseudomonas aeruginosa ) bacteria. These compounds were also tested for their inhibitory action against strains of fungi ( Candida albicans , Aspergillus niger , Aspergillus clavatus ). The synthesized compounds showed potent inhibitory action against the test organisms. |
| Databáze: | OpenAIRE |
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