The induction of inflammation in mouse tails with Aspergillus oryzae protease and the inhibitory effects of synthetic and natural sub stances in vitro
| Autor: | V. Šutiak, J. Neuschl, L. Vaško, Korenekova Beata, Sutiakova Irena, Sobekova Anna, M. Korének |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Tris
chemistry.chemical_classification Protease General Veterinary medicine.medical_treatment Substrate (chemistry) Biology Inhibitory postsynaptic potential biology.organism_classification Molecular biology In vitro Microbiology chemistry.chemical_compound Enzyme chemistry Aspergillus oryzae medicine Incubation |
| Zdroj: | Acta veterinaria. 52:345-354 |
| ISSN: | 0567-8315 |
| DOI: | 10.2298/avb0206345s |
| Popis: | Four groups of male mice were injected with doses from 0.005 to 1.0 mg of protease ex Aspergillus oryzae (PAO) in 20.0 (l of a 0.9 % physiological saline solution (PSS) per mouse s.c. into their tails. The control mice received 20.0 (l of 0.9% PSS only. The inflammation of the tails was measured volumetrically before injection and 1, 2, and 3 days afterwards. The clinical responses of the mice to PAO were observed up to 30 days. The development of inflammation corresponded well with the quantity of enzyme used. The data obtained indicated the smallest dose (0.005 mg) of PAO induced oedemization of the tail (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|