Newly generated IgE antibodies to in children are directed against components distinct from I and II
| Autor: | Rob C. Aalberse, Piet P.M. Schilte, Rupino W. Griffioen, M. Aalbers, Arnold P. Oranje, Peter G. Calkhoven, Bart-Jan L. Yntema, Jan C. van Nierop |
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| Rok vydání: | 1991 |
| Předmět: |
House dust mite
Allergy biology medicine.diagnostic_test Radioallergosorbent test Immunology Pyroglyphidae biology.organism_classification Immunoglobulin E medicine.disease Acariformes medicine.disease_cause respiratory tract diseases Allergen immune system diseases biology.protein medicine Immunology and Allergy Antibody |
| Zdroj: | Journal of Allergy and Clinical Immunology. 88:265-271 |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/0091-6749(91)90337-n |
| Popis: | The specificity of newly generated IgE antibodies (Abs) to the house dust mite, Dermatophagoides pteronyssinus, in longitudinal serum samples from 18 young children with an increased risk for IgE-mediated allergy was studied. The first IgE Ab response to house dust mite was detected early in life (mean age, 32 months; range, 11 to 60 months). For 83% of the children, more than half of the newly generated IgE Ab response to house dust mite was directed against components distinct from the major allergens, Der p I (Pl) and Der p II (DpX). These results suggest that the early IgE Ab response to house dust mite is induced by components distinct from the major allergens, Der p I and Der p II. |
| Databáze: | OpenAIRE |
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