Design, synthesis and molecular docking of novel structural hybrids of substituted isatin based pyrazoline and thiadiazoline as antitumor agents
| Autor: | Sarangapani Manda, Anvesh Jallapally, Ravi Jarapula, Sriram Rekulapally, Kiran Gangarapu, Gouthami Thumma |
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| Rok vydání: | 2017 |
| Předmět: |
Antitumor activity
chemistry.chemical_classification 010405 organic chemistry Stereochemistry Isatin Organic Chemistry Pyrazoline 01 natural sciences In vitro 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Enzyme chemistry Epidermal Growth Factor Receptor Kinase Design synthesis Docking (molecular) 030220 oncology & carcinogenesis General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Medicinal Chemistry Research. 26:819-829 |
| ISSN: | 1554-8120 1054-2523 |
| DOI: | 10.1007/s00044-017-1781-5 |
| Popis: | Cancer, which is considered to be the world’s most serious illness cause 8.2 million deaths and this rate may double by 2030. We herein report a new series of 3-(2-(p-substituted)-2-((5-phenyl-1,3,4-thiadiazol-2-yl)imino)-2-(p-substituted)ethylidene)indolin-2-one (15–19) and 5-substituted-5′-substituted phenyl-2′,4′-dihydrospiro[indoline-3,3′-pyrazol]-2-one derivatives (20–24) as potent anticancer agents. These compounds were evaluated for in vitro antitumor activity against the National Cancer Institute panel of 60 cancer cell lines. Among all the synthesized compounds, two compounds 15 and 16 showed remarkable antitumor activity with GI50 (MG-MID) values of 0.65 & 0.72 µM, respectively against Non-small cell lung cancer. To gain insight for mode of binding with Epidermal Growth Factor Receptor kinase enzyme, these compounds were further subjected to docking studies. |
| Databáze: | OpenAIRE |
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