Drug-induced muscle damage
| Autor: | G. A. Brazeau |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Drug
biology business.industry Basic science media_common.quotation_subject fungi food and beverages Muscle weakness Skeletal muscle Pharmacology medicine.disease Extensor digitorum longus muscle medicine.anatomical_structure Toxicity medicine biology.protein Creatine kinase medicine.symptom business Rhabdomyolysis media_common |
| Zdroj: | Oxidative Stress in Skeletal Muscle ISBN: 9783034898447 |
| DOI: | 10.1007/978-3-0348-8958-2_19 |
| Popis: | In recent years, numerous reports in the clinical and basic science literature have suggested that systemic drug administration can cause damage to skeletal muscle. The extent of skeletal muscle damage can range from that which is minor and self-limiting following drug discontinuation, to muscle weakness which may or may not be ameliorated following drug discontinuation, to rhabdomyolysis which, if not treated, can lead to acute renal failure and even death. The mechanisms of drug-induced toxicity are numerous and can range from disruption of intracellular calcium homeostasis, to depletion of cellular energy sources, to free radical mediated mechanisms. This chapter will examine specifically those drugs or substances of abuse which have been shown to cause toxicity to skeletal muscle. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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