Clinical and Experimental Evaluation of Diagnostic Significance of Alpha-Fetoprotein and Osteopontin at the Early Stage of Hepatocellular Cancer
| Autor: | Keerthi Kurma, C. Charrat, S. I. Malov, N. D. Yushchuk, Thomas Decaens, Zuzana Macek-Jilkova, I. V. Malov, Patrice N. Marche, N. P. Peretolchina |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Hepatocellular cancer biology business.industry General Medicine Diethyl nitrosamine medicine.disease digestive system diseases General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Hepatocellular carcinoma medicine biology.protein Cancer research Osteopontin Stage (cooking) Alpha-fetoprotein Liver cancer business Primary liver cancer 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 170:340-344 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We evaluated the possibility of using an experimental model of hepatocellular carcinoma to study oncomarkers of primary liver cancer and compared the diagnostic efficacy of alpha-fetoprotein and osteopontin in the experiment and in clinical practice. Experimental studies were performed on a model of hepatocellular carcinoma induced by administration of diethyl nitrosamine to Fisher-344 rats. In addition, the levels of α-fetoprotein and osteopontin were determined in 35 patients with hepatocellular carcinoma detected at stages I-II according to TNM classification. The proposed model of liver cancer in rats reflects the sequence of stages characteristic of hepatocellular carcinoma in humans: liver fibrosis—cirrhosis—cancer. This model is applicable for the study of tumor markers at the early stage of tumor development. Osteopontin was found to have a more powerful diagnostic potential then alpha-fetoprotein. |
| Databáze: | OpenAIRE |
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