Anticancer palladium-doped magnesia nanoparticles: synthesis, characterization, and in vitro study

Autor:	Faris A. J. Al-Doghachi, Mothanna Sadiq Al-Qubaisi, Abdullah Rasedee, Mohamed Qasim Al-Fahdawi, Rozita Rosli, Yun Hun Taufiq-Yap
Rok vydání:	2020
Předmět:	Aqueous solution biology Chemistry Magnesium Cytochrome c Biomedical Engineering Medicine (miscellaneous) Nanoparticle chemistry.chemical_element Bioengineering Development Apoptosis Cancer cell biology.protein General Materials Science Cytotoxicity Nuclear chemistry Palladium
Zdroj:	Nanomedicine. 15:547-561
ISSN:	1748-6963 1743-5889
Popis:	Aim: To prepare, physicochemically characterize and determine the anticancer effects of palladium-doped magnesia (Pd/MgO) nanoparticles. Materials & methods: Pd/MgO nanoparticles were prepared by the co-precipitation method from the aqueous solution of Mg(NO3)2.6H2O using K2CO3 and the impregnation of MgO into palladium acetylacetonate. Results: Pd/MgO nanoparticles were between 47 and 70 nm in size, cuboid in shape, and tended to form aggregates. Nanoparticles were more antiproliferative toward cancer than the normal cells. In cancer cells, Pd/MgO nanoparticles induced apoptosis by increasing caspase activities and stimulating cytochrome C release. The anticancer effects of Pd/MgO nanoparticles were accentuated by the upregulation of Bax and p53 and downregulation of Bcl-2 protein expressions. Conclusion: Pd/MgO nanoparticles have potential to be developed as an anticancer compound.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fc7e8e1ce306566544b57e970084245b https://doi.org/10.2217/nnm-2019-0178 Zobrazit plný text záznamu